Medical News | Medical Articles: dTag for Target Validation in Cancer

Medical News | Medical Articles

September 16, 2019     Genomics     The latest genomics news from News-Medical

dTag for Target Validation in Cancer dTAG (degradation TAG) is an innovative approach to target validation, using heterobifunctional small molecule Degraders to harness a cell’s protein degradation system and eliminate a protein of interest. dTAG-13 has been used to identify and validate novel targets in cancer. Learn More about dTAG

CRISPR-Cas9 successfully reverses type 2 diabetes in mice   Researchers at Hanyang University, South Korea, have used the gene-editing technology CRISPR-Cas9 to treat obesity and type 2 diabetes in mice, a development that could eventually benefit humans. The therapy specifically reduced fat tissue and reversed obesity-related metabolic disease in the animals.         SATI gene editing could replace CRISPR   The ability to edit genes within living cells and organisms at all levels, using tools like the well-known and powerful CRISPR-Cas9, is one of the most sophisticated and useful advances in modern biology. However, the technique has been limited by a myriad of safety concerns.

Scientists attempt to cure HIV using CRISPR, with varying results   Scientists have used the gene-editing technology CRISPR in an attempt to cure a person infected with HIV. The team administered human stem cells that had been engineered to resist the virus. The attempt was successful, but only to a certain extent ̶ the edited cells have survived in the man’s body for more than a year and no side effects were detected.       New method prevents the release of synthetic DNA from genetically modified cells   Scientists at Columbia University in New York have created a method that resolves two major problems commonly encountered in synthetic protein engineering. The method prevents a gene that encodes a synthetic protein from spreading into the wild and also stabilizes it so that it cannot mutate and lose its function over time.       California clamps down on amateur use of gene-editing technologies   California state officials have passed the first law to prohibit genetic biohacking in an effort to regulate the controversial practice. The new law warns biohackers not to edit their own genes and makes it illegal to sell do-it-yourself genetic engineering kits unless they clearly state that they are not to be used for self-administration.       Geneticists prove therapeutic effects of probiotics on vaginal health   Scientists have found strong evidence that three genes from Lactobacillus species, a common bacterial species found in vaginal probiotics, can mediate adhesion to the vaginal epithelium. The research could pave the way for better treatments for women with conditions such as bacterial vaginosis.

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