Themesothelioma News: Medical News | Medical Articles: Immuno-Therapeutic Antibody Discovery

Wednesday, December 11, 2019

Medical News | Medical Articles: Immuno-Therapeutic Antibody Discovery

	Immunology
	The latest immunology news from News Medical

Immuno-Therapeutic Antibody Discovery

Immuno-therapeutics capitalize on the exquisite specificity of antibody biologics to directly target tumor cells with cytotoxic agents or indirectly target tumor cells by actively recruiting other immune cells (such as T-cells and macrophages) via multi-specific antibody formats.

			The Circadian Rhythm and the Immune System The term circadian rhythm was coined to describe the oscillations in body functions observed in humans during 24 hours. The function of the circadian rhythm is to act as a regulator of cells and coordinate the internal physiological and behavioral processes in humans.

			What is Immunochemotherapy? In essence, immunochemotherapy refers to the treatment and management of disease by combining immunotherapy with chemotherapy. A vast body of research, collected over decades, has confirmed that chemotherapy (or radiotherapy) alone is not sufficient to destroy neoplastic lesions completely. The standard routine now implemented in most hospitals is that of combining chemotherapy and/or radiotherapy alongside immunotherapies.

	Functions of MHC in the Immune System The major histocompatibility complex (MHC) is a group of genes that encode proteins on the cell surface that have an important role in immune response. Their main role is in antigen presentation where MHC molecules display peptide fragments for recognition by appropriate T-cells. This is an important process in the immune system response for destroying invading pathogens.

	Vaping wrecks immune cell function, increases infection risk A new study published in the Journal of the American College of Cardiology shows that e-cigarettes have toxic effects on neutrophils function, making them a threat to human health by increasing the likelihood of infection with Gram-negative bacteria.

	Vaccination against HIV can be counterproductive if it triggers the wrong type of immune response A discovery could help immunologists design vaccines that are more effective in protecting against HIV infection. Several non-human primate studies looking at HIV's relative – SIV – provided evidence that creating too many soft targets can weaken vaccination that would have otherwise protected against infection.

	Gallstone formation may be driven by neutrophils For decades, doctors have known that gallstones assemble and grow from cholesterol and calcium crystals as the salts accumulate and stick together in bile – the yellowish-brown fluid that helps break down lipids in the small intestine. However, one hurdle that researchers have been unable to overcome in the development of new treatments is that they have not known how the calcium and cholesterol crystals stick together to form the stones.