Pediatric methylation class HGNET- MN1 : unresolved issues with terminology and grading | Acta Neuropathologica Communications | Full Text

Pediatric methylation class HGNET- MN1 : unresolved issues with terminology and grading | Acta Neuropathologica Communications | Full Text

Acta Neuropathologica Communications

Pediatric methylation class HGNET-MN1: unresolved issues with terminology and grading

• Arnault Tauziède-Espariat, 
• Mélanie Pagès, 
• Alexandre Roux, 
• Aurore Siegfried, 
• Emmanuelle Uro-Coste, 
• Yvan Nicaise, 
• Annick Sevely, 
• Marion Gambart, 
• Sergio Boetto, 
• Martin Dupuy, 
• Pomone Richard, 
• Romain Perbet, 
• Matthieu Vinchon, 
• Sabine Caron, 
• Felipe Andreiuolo, 
• Albane Gareton, 
• Emmanuèle Lechapt, 
• Fabrice Chrétien, 
• Stéphanie Puget, 
• Jacques Grill, 
• Nathalie Boddaert, 
• Pascale Varlet & 
• on behalf of the RENOCLIP-LOC

Acta Neuropathologica Communications volume 7, Article number: 176 (2019) Cite this article

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High-grade neuroepithelial tumor with MN1 alteration (HGNET-MN1) is a rare, recently described central nervous system (CNS) entity with a distinct methylation profile, which was formerly part of CNS-primary neuroepithelial tumors (PNET). HGNET-MN1 affects children (77% of reported cases [1,2,3,4,5]) and are characterized by a recurrent fusion implicating the MN1 (meningioma 1) gene [1]. Limited histopathological and clinical data are available on HGNET-MN1 (44 cases proven by DNA methylation analysis) and a number of outstanding issues still exist [1,2,3,4,5].