Themesothelioma News: Medical News | Medical Articles: What are you missing with MMR by IHC testing alone?

Thursday, November 21, 2019

Medical News | Medical Articles: What are you missing with MMR by IHC testing alone?

	Gastroenterology‎
	The latest gastroenterology‎ news from News Medical

What are you missing with MMR by IHC testing alone?

CIHC can miss up to 10% of dMMR tumor samples. Current guidelines recommend co-testing tumor samples using both MSI by PCR and MMR by IHC, decreasing the number of mischaracterized tumor samples to less than 1%.

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			Research finds lower bone density among adults with undiagnosed celiac disease Research by George Mason University College of Health and Human Services found that adults who likely had undiagnosed celiac disease had lower bone density than the adults without UCD, although they consumed more calcium and phosphorous.

			Colorectal surgery patients in ERAS program report less pain, use fewer opioids Colorectal surgery patients who were a part of an enhanced recovery after surgery program had less pain, while using nearly half as many opioids, according to research being presented at the ANESTHESIOLOGY 2019 annual meeting.

	New treatment shows promise to reverse celiac disease Results of a new phase 2 clinical trial using technology developed at Northwestern Medicine show it is possible to induce immune tolerance to gluten in individuals with celiac disease. The findings may pave the way for treated celiac patients to eventually tolerate gluten in their diet.

	New study sounds a note of caution in using probiotics in ICU It's become common for patients in the intensive care unit (ICU), both children and adults, to receive probiotics. Often, they are started at home to counteract diarrhea caused by antibiotics. There is also interest in using probiotics proactively in the ICU. A large multicenter clinical trial in Canada is testing whether probiotics would prevent ventilator-associated pneumonia in adult ICU patients.

	SEPATH: New template to detect oncogenic viruses and bacteria in human DNA A new study from the University of East Anglia describes a novel approach to detecting bacteria and viruses that may possibly be causing cancer. Many such associations have already been found, such as HPV (human papilloma virus) infection in cervical cancer, and Helicobacter pylori (H. pylori) in stomach cancer.

	Study reveals novel druggable driver gene in human gastrointestinal stromal tumors Sarcomas - cancers that arise from transformed mesenchymal cells (a type of connective tissue) - are quite deadly. Gastrointestinal stromal tumors are the most common human sarcoma and are initiated by activating mutations in the KIT receptor tyrosine kinase.

	New insights into how immune system and inflammation play a role in PD Relatively new research findings indicating that the earliest stages of Parkinson's disease (PD) may occur in the gut have been gaining traction in recent years. In a review published in the Journal of Parkinson's Disease, Tomasz Brudek, PhD, evaluates evidence for the association between inflammatory bowel disease (IBD) and PD and proposes directions for future research.