Genomic profiling in pancreatic ductal adenocarcinoma and a pathway towards therapy individualization: A scoping review. - PubMed - NCBI

Genomic profiling in pancreatic ductal adenocarcinoma and a pathway towards therapy individualization: A scoping review. - PubMed - NCBI

Cancer Treat Rev. 2019 Mar 22;75:27-38. doi: 10.1016/j.ctrv.2019.03.003. [Epub ahead of print]

Genomic profiling in pancreatic ductal adenocarcinoma and a pathway towards therapy individualization: A scoping review.

Singh RR1, Goldberg J2, Varghese AM3, Yu KH3, Park W3, O'Reilly EM4.

Author information

Abstract

CONTEXT:

Pancreatic cancer (PDAC) is one of the most challenging cancers to treat with modest recent improvements in survival from new systemic therapies. There is growing interest in individualized therapy underpinned by somatic and germline genomic alterations.

OBJECTIVE:

A systematic review of data on therapies targeting somatic and germline alterations, and their downstream pathways in PDAC.

METHOD:

A systematic literature search was conducted using PRISMA guidelines to include relevant results published after January 1, 2008.

RESULTS:

A total of 71 relevant studies were included. We identified 36 studies targeting the KRAS-pathway, the most common being with MEK-inhibitor therapy. Twenty-two studies were identified that evaluated platinum-based chemotherapy and PARP inhibitors in patients with deleterious mutations in DNA damage repair genes and have shown encouraging results. Immunotherapy has demonstrated activity in patients with mismatch repair deficiency/microsatellite instability.

CONCLUSION:

Evidence from translational and clinical research presents an exciting platform for genomic targeted therapy in PDAC. Validity for targeting BRCA with platinum and PARP inhibitors and microsatellite instability with immune therapy has been established, nonetheless, evidence for targeting the common driver oncogenes is lacking and much work is needed. Of importance is identifying the subgroup of KRAS -wild type PDAC (approximately 5%) where there is enrichment for targetable opportunities.

Copyright © 2019 Elsevier Ltd. All rights reserved.

KEYWORDS:

DNA damage repair; Genomic alteration (GA); Germline mutation; Microsatellite instability; Mismatch repair (MMR); Pancreatic ductal adenocarcinoma (PDAC); Somatic mutation

PMID:

 

30927677

 

DOI:

 

10.1016/j.ctrv.2019.03.003