Chemical Imaging for Biomedicine: The Next Frontier of Light Microscopy

Life Science Microscopy     The latest life science microscopy news from AZoNetwork

Chemical Imaging for Biomedicine: The Next Frontier of Light Microscopy Metabolites and drugs are hard to visualize because they are mostly small molecules, do not emit fluorescence and cannot be labeled with the large fluorophores. However, they are very important in biomedicine because a lot of diseases are related to abnormalities in metabolism. This article describes the development of new imaging techniques to overcome these challenges: Bioorthogonal Chemical Imaging for small metabolites and Super Multi-Color Imaging. Read More

Types of Scanning Probe Microscopy   There are several different types of scanning probe microscopes, the most prominent of which are atomic force microscopy (AFM) and scanning tunneling microscopy (STM). There are also many other types, which are listed at the end of this article.         Avoiding Cell Death in Fluorescence Microscopy   Fluorescence microscopy is a common laboratory tool used to investigate the physiology of different cells. Specific wavelengths of light are shone onto cells in a sample, where the light is absorbed by molecules called fluorophores.

Microsphere-Assisted Microscopy: Advantages and Limitations   Transparent microspheres can generate an image with a super-resolution of 50 nanometers. This technique provides several advantages over conventional imaging and confocal microscopy.       E-FRET Microscopy for Live Cell Imaging   E-FRET microscopy recently became a very popular intensity-based Fluorescence Resonance Energy Transfer (FRET) method for cell quantification. This technique reduces the photobleaching observed during the process of FRET.       Applications of Cryo-Electron Microscopy   Higher resolution of any image is achieved by the wavelength of the radiation used for imaging. A typical electron microscopy uses a beam of electrons in the wavelength of ~ 0.02å for operation at 300kV.       Portable mini microscope could improve scientists' ability to study brain disease in living mice   Working with mice, a team of Johns Hopkins Medicine researchers has developed a relatively inexpensive, portable mini microscope that could improve scientists' ability to image the effects of cancer, stroke, Alzheimer's disease and other conditions in the brains of living and active mice over time.

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