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Wednesday, January 8, 2020

Medical News | Medical Articles | hiPSC-Derived Cortical Neuron Response to Pharmaceuticals

	Biochemistry
	The latest biochemistry news from AZoNetwork

hiPSC-Derived Cortical Neuron Response to Pharmaceuticals

The functional network of human-induced pluripotent stem cell (hiPSC)-derived neurons is a highly potent in vitro model for assessing drug responses and disease mechanisms.

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			What is Binding Activated Localization Microscopy (BALM?) In the field of super-resolution microscopy, single-molecule localization microscopy (SMLM) is a fast-evolving technique that allows researchers to study subcellular structures and the dynamics of single molecules at the nanoscale. SMLM works by isolating single fluorescent molecules from each other based on one or more of their distinguishing optical characteristics.

			An Overview of Caspase Activity Caspases are proteases: enzymes that catalyze the breakdown of proteins and are part of the cysteine–aspartic acid protease family. They are vital to the mechanism of programmed cell death in animals (apoptosis, pyroptosis, and necroptosis), and also play a fundamental role in inflammation.

	Novel nanopipette pH biosensor could help with cancer diagnosis and treatment Nanopipettes with zwitterionic membranes may offer improved monitoring of changes in pH surrounding living cells, which can indicate traits of invasive cancer cells and their response to treatment, report researchers at Kanazawa University in Nature Communications.

	Imaging Nuclear Structures Using AFM Since the advent of scanning probe microscopy (SPM) with the invention of the scanning tunneling microscope in the 1980s, scientists have had an alternative to scanning electron microscopy (SEM) to image target samples.

	New Electronic Biosensor Powers Itself Using Glucose in Bodily Fluids Researchers from KAUST have created an electronic biosensor that is powered by the glucose present in bodily fluids. The device couples an electron-transporting polymer with an enzyme that derives electrons from its reaction with glucose to power its circuitry.

	New technique could lead to better diagnosis and effective tracking of Huntington’s disease Researchers at the universities of Southampton and Cambridge have developed a new technique to analyze biochemical changes unique to Huntington's disease. The breakthrough has the potential to lead to the improved diagnosis of disease onset and possibly better ways to track the effects of new treatments.