Themesothelioma News: Medical News | Medical Articles: Formulation screening of mAbs and ADCs

Wednesday, February 19, 2020

Medical News | Medical Articles: Formulation screening of mAbs and ADCs

	Antibodies
	The latest antibodies news from News Medical

Formulation screening of mAbs and ADCs

Linking hydrophobic drugs to stable mAbs makes antibody-drug conjugates highly prone to aggregation. Learn how high-throughput screening by DLS contributes to rapid and effective formulation of stable ADCs.This application note demonstrates how high-throughput dynamic light scattering (DLS) with automated well-plate sampling using the DynaPro Plate Reader and DYNAMICS software enables the rapid and reliable characterization of two ADCs based on monoclonal antibodies (mAb) IgG1 and IgG2.

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			The Differences Between Monoclonal and Polyclonal Antibodies This article discusses the differing key features and applications of polyclonal and monoclonal antibodies.

			A Comparison of Immunohistochemistry and Western Blot Immunohistochemistry and Western blotting both work by exploiting the principle of how antibodies specifically bind to the antigens present in biological tissue.

	What are Biotinylated Antibodies? The term biotinylation refers to the process of binding biotin to either a protein or a nucleic acid, or in some cases to another type of molecule.

	Uses of Histone Deacetylase (HDAC) Antibodies in Research Histone deacetylase (HDAC) antibodies are used to study the process of histone deacetylation, an essential activity that happens within human cells.

	HIV antibody therapy improves immune function A new study published in the journal Nature Medicine in February 2020 reports that the administration of neutralizing antibodies against HIV improve the recipient’s specific T cell responses against the virus.

	What are Anti-PEG Antibodies and Why are they Useful? PEG, or polyethylene glycol, is a synthetically constructed polymer, made of repeating units of ethylene glycol (-CH2-CH2-O-).