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Monday, November 11, 2019

Medical News | Medical Articles: Tips, tricks and solutions for effective sample management

	Genomics
	The latest genomics news from News-Medical

Tips, tricks and solutions for effective sample management

Sample management is the selecting, collecting, storage, and retrieval of samples and their inherent data. It is a fundamental part of quality control in a laboratory and, if overlooked, can have costly and time-consuming repercussions. An informative and unbiased guide is now available that addresses key topics including:

What is sample management?
Top tips for tube selection and labelling
Top tips for sample collection
The importance of an effective sample management system cannot be overstated.

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			Scientists successfully create age-resistant mice with hyper-long telomeres Researchers at the Spanish National Cancer Research Centre (CNIO) have shown that it is possible to extend the life of mice, without using any gene modifying technologies. The finding is the result of a study launched some years ago that aimed to investigate mice with hyper-long telomeres.

			New method prevents the release of synthetic DNA from genetically modified cells Scientists at Columbia University in New York have created a method that resolves two major problems commonly encountered in synthetic protein engineering. The method prevents a gene that encodes a synthetic protein from spreading into the wild and also stabilizes it so that it cannot mutate and lose its function over time.

	Scientists use ultrasound to detect active genes in live cells A startling new study published in the journal Science shows that ultrasound can help scientists to understand whether specific genes are in the active or inactive state in live cells. This incredible feat promises to transform the way scientists examine a host of living cell activities, ranging from the growth of tumors to neuron function.

	Novel viral vector improves gene therapy for sickle cell disease Researchers at the National Institutes of Health (NIH) have developed a unique, improved viral vector to use in gene therapy for sickle cell disease. Using animal models, the new vector was shown to support the transfer of corrective genes into bone marrow stem cells up to ten times more efficiently than current vectors. It also had a carrying capacity that was ten times greater than conventional vectors.

	Machine learning reveals links between genetic factors and behavior Researchers at the University of Utah Health have used machine learning to start making links between seemingly instinctive, random behaviors and the genetic factors that shape such behaviors. Using machine learning to study mice with differences in their genetics and age, the team found that these differences influenced the behavioral sequences the animals expressed while they foraged for food.

	Improved Cas9 enzyme reduces chance of off-target CRISPR mutations Genomics experts are finding new ways to improve the use of the enzyme Cas9 for CRISPR gene-editing to reduce the likelihood of off-target mutations. The research, which addresses concerns about off-target mutagenesis and identifies new ways to improve precision, was recently presented at the American Society of Human Genetics 2019 Annual Meeting in Houston.