Iatrogenic early onset cerebral amyloid angiopathy 30 years after cerebral trauma with neurosurgery: vascular amyloid deposits are made up of both Aβ40 and Aβ42 | Acta Neuropathologica Communications | Full Text

Iatrogenic early onset cerebral amyloid angiopathy 30 years after cerebral trauma with neurosurgery: vascular amyloid deposits are made up of both Aβ40 and Aβ42 | Acta Neuropathologica Communications | Full Text

Acta Neuropathologica Communications

Iatrogenic early onset cerebral amyloid angiopathy 30 years after cerebral trauma with neurosurgery: vascular amyloid deposits are made up of both Aβ40 and Aβ42

• Giorgio GiacconeEmail author,
• Emanuela Maderna,
• Gianluca Marucci,
• Marcella Catania,
• Alessandra Erbetta,
• Luisa Chiapparini,
• Antonio Indaco,
• Paola Caroppo,
• Anna Bersano,
• Eugenio Parati,
• Giuseppe Di Fede and
• Luigi Caputi

Acta Neuropathologica Communications20197:70

https://doi.org/10.1186/s40478-019-0719-1

©  The Author(s). 2019

• Received: 11 March 2019
• Accepted: 12 April 2019
• Published: 2 May 2019

Aβ protein is the main component of the amyloid of Alzheimer disease (AD) that builds up extracellularly in the neuropil as senile plaques (SP) and in the vessel walls as cerebral amyloid angiopathy (CAA) [14]. In some cases, CAA dominates pathologically over SP and this corresponds to a clinical presentation with multiple cerebral hemorrhages rather than degenerative dementia. The former can either present as a sporadic disease or as an hereditary condition (cerebral hemorrhage with amyloidosis, HCHWA) associated with specific APP mutations [3, 13].